Sustained release of ciprofloxacin from an osteoconductive poly(DL)-lactide implant

Sustained and localized in vitro release of BMP-2/7, RANKL, and tetracycline from FlexBone, an elastomeric osteoconductive bone substitute.

We tested the hypothesis that synthetic composites containing a high percentage of osteoconductive biominerals well-integrated with a hydrophilic polymer matrix can be engineered to provide both the structural and biochemical framework of a viable synthetic bone substitute. FlexBone, an elastic hydrogel-mineral composite exhibiting excellent structural integration was prepared by crosslinking p...

Sustained and Localized In Vitro Release of Vancomycin and rhBMP-2 from an Elastomeric Osteoconductive Synthetic Bone Graft Substitute

INTRODUCTION: Current treatment of patients with significant volumetric bone loss or segmental bone defect involves either utilization of autograft (current standard) or allograft. These methods are associated with patient morbidity and multiple complications. Development of synthetic bone grafts that will mimic the structural compositions of human bone and provide elastomeric handling properti...

Sustained Release of Green Tea Polyphenols from Liposomal Nanoparticles; Release Kinetics and Mathematical Modelling

Background: Green tea polyphenols (GTP) are known to have several health benefits. In spite of these benefits, its application as a therapeutic agent is limited due to some of its limitations such as stability, bioavailability, and biotransformation. To overcome these limitations, liposomal nanoparticles have been used as a carrier of the GTP. <spa...

Development of Glyceryl Monostearate Based Ciprofloxacin Hydrochloride Sustained Release Matrix Tablet: an In vitro Study

In this present study an attempt has been made to evaluate glyceryl monostearate (GMS) as a rate retarding material to sustain the release ciprofloxacin hydrochloride from the matrix tablet. The solubility of ciprofloxacin hydrochloride was studied. The physical parameters of the prepared tablets were also evaluated. Release kinetics of ciprofloxacin hydrochloride from this sustained release ma...

preparation and characterization of tri-block poly(lactide)- poly(ethylene glycol)- poly (lactide) nanoparticles for sustained release of rivastigmine